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The journal «ONCOSURGERY» 2013, Vol.5, No 2

Prevention and management of radiation-induced skin injuries

Musabaeva L.I.1, Velikaya V.V.1, Gribova O.V.1, Startseva Zh.A.1, Aleinik A.N.2

1) Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences,
2) National Research Polytechnic University,
Tomsk, Russia
Contact: Musabaeva Ludmila Ivanovna, e-mail:

The aspects of prevention and management of early radiation-induced injuries and late injuries of skin in patients with different malignant tumors were review.

Material and methods. Analysis of current treatment for radiation-induced injury of skin in patients with classic photon therapy and intraoperative radiotherapy with additional gamma-therapy on breast, neutron and neutron and photon therapy in patients with head and neck cancer, local recurrences of breast cancer was performed. Development of methods for prevention and management of radiation-induced skin injury at radiation field in patients with fast neutron therapy of 6.3 MeV is topical, because the maximum of fast neutron dose is directly in skin – by 1.2 mm from surface resulting in early radiation-induced injury of tissue.

Radiation-induced reactions and late injuries of skin at radiation field in the head and neck area depending on fractionation schedule of fast neutron dose are described. The calculation of absorbed dose for treatment planning is performed regarding to adjustment for radiated tissue area and heterogeneity of fat layer allowing to decrease radiation exposure on skin of radiation field by 30-40%. The effective method for prevention and management of radiation-induced skin injuries with laser on copper vapour was developped. Evidence for benefit from application of Tizol for early radiation-induced skin injuries and ozone therapy in patients with late radiation-induced ulcer at long-term period for local recurrences of breast cancer is shown.

Conclusion. The search for new effective agents and necessary physical methods for prevention and management of radiation-induced reactions and late injuries of skin and adjacent normal tissues at radiation field in patients with radiotherapy using different types of ionizing radiation is continued. This problem is the most relevant for fast neuron therapy which is densely ionizing radiation and produces prominent radiation-induced reactions, injuries of skin and mucosa.

KEY WORDS: radiation-induced reaction and injury of skin; methods of radiotherapy; prevention and management.

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