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The journal «ONCOSURGERY» 2014, Vol.6, No 1

Skin melanomas clinical and epidemiological features in the Mari El Republic

Muhamatgaleeva LH1, Afanasieva ZA2, Polyakov VV1

1) Oncological Dispensary, Ioshkar-Ola, Mari El Republic Russia
2) Kazan State Medical Academy of Russian Federation Health Ministry, Kazan, Russia
Contact: Mukhamatgaleeva Luiza Albertovna, e-mail:

Article describes scin melanoma epidemiological, clinical and histopatological features in Mari El Republic.

Materials and methods. The retrospective analysis of 253 patients with first diagnosed skin melanoma is carried out. All patient were treated in Mari El Republic Oncological dispensary since 2003 to 2012 years.

Results. In Mari El republic we revealed the resistant tendency of skin melanoma incidence rate as well as in Russian Federation.

Skin melanoma we diagnosed more in women (63,2% cases), the correlation between women and men was 1,7:1. Skin melanoma was more diagnosted among urban population in 68,8% cases. Ioshkar-Ola city and Volzhsk town were in the lead. Patients of the fifth and sixth life decades were in 49,4% cases (50-59 years in 27,3%, 60-69 years in 22,1%). Able-bodied age people, including 58 men (62,4%) and 62 women (38,8%) were treated.

Skin melanoma in men was more frequently localized on the trunk (22,1%), especially on the back (15%). Skin melanoma in women was equally often localized on the trunk (20,2%) and lower extremities (20,2%).

According to patomorfological in 76,7% cases (194 patients) the tumor contained a pigment, and in 49,4% cases (125 patients) were diagnosed 3rd invasion level by Clark.

In 20,9% cases (53 patients) skin melanoma was classified as III-IV stage, that did not forecast successful treatment.

Conclusion. In Mari El Republic since 2003 to 2012 the resistance tendency of skin melanoma incidence rate is revealed. Frequency and structure of this pathology are characterized by geographical, age and sexual features. Skin melanoma mobidity in women is almost twice more, than in men. More often skin melanoma affects people in the 5-6th life decade, it is localized on trunk and the lower extremities. Mainly the pigmentary melanoma with the 3rd invasion level by Clark takes place, so this disease is late diagnosed.

So, according to our research skin melanoma must be valued as medical, social and economic problem for Mari El Republic.

KEY WORDS: skin melanoma, Mari El Republic.


  1. Sokolov DV, Vorozhtsov GN, Makhson AN, Kuzmin SG. A comprehensive method for early diagnosis of melanoma. Rossiyskiy onkologicheskiy zhurnal 2008; 4: 6-10.
  2. Lemekhov VG. Epidemiology, risk factors, screening melanoma.. Prakticheskaya onkologiya, 2001; 4 [8]: 3-11.
  3. Demidov LV, Sokolov DV, Bulycheva IV, et al. Improvement of methods of diagnosis of melanoma. Vestnik RONC im. N.N.Blokhina RAMN 2007; 18: 1: 36-41.
  4. Liu S, Kirschmeier P, Simon J, et al. Prognostic and Predictive Molecular Markers in Cutaneous Malignant Melanoma: The First Step Toward Personalized Medicine. Current Pharmacogenomics and Personalized Medicine, 2008; 6: 272-94.
  5. Rodríguez-Cerdeira С, Molares-Vila A. New Perspectives of “omics” Applications in Melanoma Research. Open Biochem J, 2011; 5: 60-6.
  6. Varughese BE, Tarapore RS. Genes and signaling pathways affecting the pathogenesis of melanoma. J Postdoctoral Research, 2013; 1: 51-67.
  7. Bennassar A, Ishioka P, Vilalta A. Surgical treatment of primary melanoma. Dermatologic Therapy, 2012; 25: 432-42.
  8. Borovskaya TF, Marochko AYu, Mashenkina YaA, Kurpas EKh. Clinico-prognostic significance of molecular biomarkers suppression of tumor growth, proliferation, and their regulators in melanoma. Dalnevostochnyiy meditsinskiy zhurnal, 2010; 1: 119-122.
  9. Anisimov VV. Standard examination of patients with suspected melanoma. Modern clinical classification . Sovremennaya klinicheskaya klassifikatsiya. Prakticheskaya onkologiya, 2001; 4 [8]: 12-22.
  10. Chissov VI, Starinskiy VV, Petrova GV. Malignancies in Russia in 2011 (morbidity and mortality). FGBU «MNIOI im. P.A. Hertsena» MZ RF, M. 2013; 289.
  11. Markovic SN, Erickson LA, Rao RD, et al. Malignant Melanoma in the 21st Century. Part 1: Epidemiology, Risk Factors, Screening, Prevention, and Diagnosis. Mayo Clin Proc, 2007; 82(3): 364-380.
  12. Rigel DS, Russak J, Friedman R. The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs. Cancer J Clin 2010; 60: 301-16.
  13. Tsao H, Atkins MB, Sober AJ. Management of cutaneous melanoma. N Engl J Med, 2004; 351: 998-1012.
  14. Bulliard J-L. Site-specific risk of cutaneous malignant melanoma and pattern of sun exposure in New Zealand. Int J Cancer, 2000; 85: 627-32.
  15. Lachiewicz AM, Berwick M, Wiggins CL, Thomas NE. Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program. J Invest Dermatol, 2008; 128: 1340-2.

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