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The journal «ONCOSURGERY» 2014, Vol.6, No 1

Experimental feasibility and clinical application of Tissucol in rehabilitation after oncological surgery

Novogilova EN1, Fedotov AP1, Novogilov MV1, Olshanskaya OV2, Schupak MU1

1) Moscow city oncological hospital #62,
2) IM Sechenov First Moscow State Medical University,
the department of analytical, physical, and colloid chemistry, the chief of department,
Moscow, Russia
Contact: Olshanskaya Olga Vladimirovna, e-mail:

First experience with fibrin glue Tissucol Kit (Baxter) in Moscow city oncological hospital #62 is represented in the article. The fibrin glue Tissucol Kit is a lysate of binding protein including fibrinogen, fibronectin, factor ХIII, plasminogen and aprotinin solution. Through its action elastic and stable fibrin clot securing hemostasis and healing of surrounding tissue is developed.

Authors used this medicine in different clinical circumstances (for consolidation of pharyngeal sutures, for lymphorrhea management). However Tissucol Kit was the most effective in patients with excessive and continuous lymphorrhea for which management with conventional methods was failured. Detailed description of use of this medicine according to area and volume of wound surface is represented. The case report demonstrates vividly possibilities of Tissucol Kit and allows to recommend it for application in other fields of oncology.

KEY WORDS: Tissucol Kit, fibrin glue, wound healing.


  1. Tissukol patient information leaflet.
  2. Redl H, et al. The influence of lonic additives on fibrin structure and on the morphology and growth of human fibroblasts. Comparison of two fibrin glues. Med Welt 1995; 85(22): 769-77.
  3. Gouillat C, Tete B, Frering V, et al. Evaluation of the effectiveness of two fibrin glues for patients undergoing resternotomy or reoperation after cardiac operations. multicentral study. J Thorac Cardiovasc Surg 1999; 87: 234-53.
  4. Severtsov AN, Brekhov EI, Mironov NP, Ivanova EN, Repin IG. Using of local pharmacological agents to achieve a final hemostasis in operations on liver. Khirurgiya 2001; 1: 86-91.

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